celine galvagnion | Staff – University of Copenhagen celine galvagnion Céline Galvagnion-Büll. Associate Professor. Molekylær og cellulær farmakologi. https://drug.ku.dk/ Jagtvej 160. København Ø. E-mail:
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0 · Céline Galvagnion
1 · Staff – University of Copenhagen
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Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, .
Céline Galvagnion-Büll. Associate Professor. Molekylær og cellulær farmakologi. https://drug.ku.dk/ Jagtvej 160. København Ø. E-mail: [email protected]. Telephone: +4535337828. View research .
Céline Galvagnion
Staff – University of Copenhagen
Céline Galvagnion says: “Ageing is the highest risk factor for Parkinson’s Disease (PD). PD is characterised by the loss of specific cells and the deposition of protein clumps in specific areas in patients’ brains. The rationale behind this selective vulnerability is not yet understood although required for a better understanding of the .Alzheimer's disease is a neurodegenerative disorder associated with the aberrant aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol in the pathogenesis of Alzheimer's disease, the detailed mechanistic link between this lipid molecule and the disease process remains to be fully established. Small unilamellar vesicles composed of the negatively charged lipid DMPS enhance the aggregation of the Lewy Body disease protein α-synuclein by increasing the rate of primary nucleation by a . [email protected] +45 35337828. Follow us. Linkedin. Twitter %d. In this study, we discovered the shared lipid signature associated with long sporadic Parkinson’s disease (PD) (sPD), GBA risk and mild mutations, that is distinct from that of GBA severe mutation in PD amygdala. . Galvagnion Group. University of Copenhagen Jagtvej .
I joined the Galvagnion group in September 2023 as a research assistant responsible for the work related to generating iPSC models of Parkinson’s disease. When I am not taking care of cell cultures I enjoy hanging out with friends, running, and learning new creative hobbies . [email protected] +45 35337828. Follow us. Linkedin .2023 DFF project 1. Céline Galvagnion received a DKK 2,879,534 grant from Danmarks Frie Forskningsfond for the project “Understanding the cytotoxicity of protein-lipid aggregates in Parkinson’s Disease”. This project aims to investigate the toxicity of protein-lipid aggregates and fibrils in different cellular models of Parkinson’s Disease.Céline Galvagnion-Büll. Associate Professor. Molekylær og cellulær farmakologi https://drug.ku.dk/ Jagtvej 160 København Ø E-mail: [email protected] Telephone: +4535337828 View research profile and publications Department of Drug Design and Pharmacology University of Copenhagen .Céline Galvagnion-Büll. Associate Professor. Molekylær og cellulær farmakologi https://drug.ku.dk/ Jagtvej 160 København Ø E-mail: [email protected] Telephone: +4535337828 View research profile and publications Department of Drug Design and Pharmacology University of Copenhagen .
It is now well established that the aberrant conversion of peptides or proteins from their native functional states into toxic amyloid entities underlies the pathogenesis of a wide range of debilitating human diseases, collectively known as protein misfolding disorders (PMDs). [email protected] +45 35337828. Follow us. Linkedin. Twitter %d. Jesper, Krista, Celine, and Kathi proudly represented both the Galvagnion Group and the University of Copenhagen in this year’s DHL Team Run. Menu. Close. Research; Location; News; Publications; People . Introduction. Cytoplasmic aggregates of the protein α-synuclein are the pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies (Spillantini et al., 1997).Point mutations in the α-synuclein gene or triplication of the α-synuclein locus are associated with familial forms of PD, and the α-synuclein locus is a genetic risk factor for .
[email protected] +45 35337828. Follow us. Linkedin. Twitter %d. The ISBUC Annual Meeting is a full-day event fostering interdisciplinary exchange among structural biologists, highlighting the latest advancements and integrative approaches in the field. This year, Jesper Elmsted Dreier made a standout contribution with his poster . The deposition of coassemblies made of the small presynaptic protein, α-synuclein, and lipids in the brains of patients is the hallmark of Parkinson's disease. In this study, we used natural abundance 13C and 31P magic-angle spinning nuclear magnetic resonance spectroscopy toge .Céline Galvagnion-Büll, Associate Professor in Biophysical Pharmacology. She has been a researcher at ILF since 2019, where she has been conducting her research within the field of molecular and cellular biology, examining the development of neurodegenerative diseases.
Galvagnion, C. et al. Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. Proc. Natl Acad. Sci. USA 113, 7065–7070 (2016).Céline Galvagnion 1 2 Affiliations 1 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. 2 Institute of Physical Biology, Heinrich Heine Universität, Düsseldorf, Germany. PMID: 28671142 DOI: 10.3233/JPD-171103 Abstract α-synuclein is a small protein abundantly expressed in the brain and mainly located in synaptic terminals. . The self-assembly of α-synuclein is closely associated with Parkinson's disease and related syndromes. We show that squalamine, a natural product with known anticancer and antiviral activity, dramatically affects α-synuclein aggregation in vitro and in vivo. We elucidate the mechanism of action of s .Celine Galvagnion Associate Professor at University of Copenhagen, Department of Drug Design and Pharmacology 11mo Report this post We are continuing our journey to a more sustainable way to do .
Email: [email protected]. New positions will be posted here and in the news tab when available. Open positions. There are no current open positions in our group. Galvagnion Group. University of Copenhagen Jagtvej 160, 2100, København Ø, Denmark. Contact us. [email protected] +45 35337828. Follow us.Electronic address: [email protected]. PMID: 33832803 DOI: 10.1016/j.bpc.2020.106534 Abstract Mutations in the gene GBA, encoding glucocerebrosidase (GCase), are the highest genetic risk factor for Parkinson's disease (PD). GCase is a lysosomal glycoprotein responsible for the hydrolysis of glucosylceramide into glucose and ceramide. α-synuclein is a small protein abundantly expressed in the brain and mainly located in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark of a range of neurodegenerative disorders including Parkinson’s disease and dementia with Lewy bodies. α-synuclein is disordered in solution but can adopt an α-helical conformation upon .Céline Galvagnion-Büll. Associate Professor. Molekylær og cellulær farmakologi https://drug.ku.dk/ Jagtvej 160 København Ø E-mail: [email protected] Telephone: +4535337828 View research profile and publications Department of Drug Design and Pharmacology University of Copenhagen .
Introduction. Biomolecular liquid–liquid phase separation (LLPS) is the spontaneous condensation of molecules (most prominently—proteins and nucleic acids) into a highly concentrated (“dense”) phase and a dilute phase 1 – 14.Due to the lack of a physical membrane, phase separated, liquid-like assemblies can readily exchange biomolecules with . 13 C MAS NMR spectra and dynamics of DMPS and DLPS in the pure lipid systems and within α-synuclein proto-fibrils. (A and B) 13 C CP-DP-INEPT MAS NMR spectra of the pure lipid systems (top) and of lipid-induced α-synuclein proto-fibrils (bottom) (A, DMPS; B, DLPS) measured at 60 (A) or 30 C (B), respectively. The molecular structure of DMPS (A) and .
Galvagnion et al. report that fibroblast lipid extracts from patients with Parkinson’s disease carrying the L444P GBA mutation feature an increased ratio of short chain: long chain sphingolipids. This lipid profile promotes faster α-synuclein aggregation. Ambroxol treatment reverses both sphingolipid and protein aggregation changes.
Céline Galvagnion, alexander K Buell, Georg Meisl, thomas C t Michaels, Michele Vendruscolo, tuomas p J Knowles & Christopher M dobson* a-Synuclein (a The conversion of soluble peptide and protein molecules into insoluble amyloid fibrils is of great interest in fields of science ranging from molecular medicine to nanotechnology ().The formation of amyloid fibrils is a characteristic feature of a substantial number of increasingly common medical disorders, including neurodegenerative conditions such as Alzheimer’s and .
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celine galvagnion|Staff – University of Copenhagen
